WebA first-in-human study of the anti-inflammatory profibrinolytic TMS-007, an SMTP family triprenyl phenol. T. Moritoyo, Naoko Nishimura, +13 authors K. Hasumi; Medicine, Biology. British Journal of Clinical Pharmacology. WebJan 3, 2024 · TMS-007 Overview TMS-007 (Stachybotrys microspora triprenyl phenol-7) is under development for the treatment of acute ischemic stroke. The drug candidate is administered through intravenous route. The drug candidate is produced from the culture of the filamentous fungus Stachybotrys microspora (SM) and has a structure of triprenyl …
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WebSHIBATA K, HASHIMOTO T, HASUMI K, et al. Potent efficacy of Stachybotrys microspora triprenyl phenol-7, a small molecule having anti-inflammatory and antioxidant activities, in a mouse model of acute[J]. European Journal of Pharmacology,2024,910:174496. doi: 10.1016/j.ejphar.2024.174496 WebThe moorFLPI-2 blood flow imager uses the laser speckle contrast technique to deliver real-time, high-resolution blood flow images, providing outstanding performance in a wide range of pre-clinical and clinical research applications. Optical zoom means you can assess small areas right up to a full size adult hand with a single imager. mitchell grass retreat
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WebAkamatsu Y, Saito A, Fujimura M, et al. Stachybotrys microspora triprenyl phenol-7, a novel fibrinolytic agent, suppresses superoxide production, matrix metalloproteinase-9 expression, and thereby attenuates ischemia/reperfusion injury … WebDec 23, 2024 · Its anti-inflammatory action, mediated by soluble epoxide hydrolase inhibition, may contribute to its efficacy. Evidence suggests that TMS-007 can effectively treat experimental thrombotic and embolic strokes with a wide time window, while reducing haemorrhagic transformation. WebAbstract Stachybotrydial, a triprenyl phenol metabolite from a fungus, has a plasminogen modulator activity selective to Glu-plasminogen. Stachybotrydial enhanced fibrin binding and activation of ... mitchell grass retreat longreach