WebbModularity refers to the ability of a system to organize discrete, individual units that can overall increase the efficiency of network activity and, in a biological sense, facilitates selective forces upon the network. WebbBaker CR et al (2012) Protein modularity, cooperative binding, and hybrid regulatory States underlie transcriptional network diversification. Cell 151:80–95 Nguyen VQ, Sil A (2008) Temperature-induced switch to the pathogenic yeast form of Histoplasma capsulatum requires Ryp1, a conserved transcriptional regulator.
Protein Modularity, Cooperative Binding, and Hybrid Regulatory …
Webb1 maj 1996 · This hydrophobic patch is required for cooperative DNA binding with Mcm1 in vitro and for transcriptional repression in vivo. We have also found that a conserved motif, termed YPWM, frequently found in homeodomain proteins of insects and mammals, partially functions in place of the patch in alpha2 to interact with Mcm1. Webb28 sep. 2012 · Protein modularity, cooperative binding, and hybrid regulatory states underlie transcriptional network diversification. We examine how different … elizabeth nm
SFB 680 Molecular Basis of Evolutionary Innovations journal club
Webb7 maj 2013 · Modularity provides a simple mechanism for the evolution of cooperation without having to invoke complicated mechanisms such as reputation or punishment, or … Webb11 nov. 2024 · Exchanges of protein sequence modules support leaps in function unavailable through point mutations during evolution. Here we study the role of the two RAD51-interacting modules within the eight binding BRC repeats of BRCA2. We created 64 chimeric repeats by shuffling these modules and measured their binding to RAD51. Webb25 maj 2007 · Based on the study of an additional functionally annotated dataset of 115 proteins, we propose that high-modularity modules include functional sites and are the basic functional units. We provide examples (the Gα s subunit and P450 cytochromes) to illustrate that the modular architecture of active sites is linked to their functional … elizabeth noll department of energy