Pin1 mutant
WebJul 15, 2024 · Pin1 is also a positive regulator of tumor suppressors P53 ( 12–14) and p73 ( 15, 16 ), although, in cancer, stabilization by Pin1 can enhance the oncogenic activity of mutant, pathogenic P53 ( 17 ). In DNA double-strand break (DSB) repair, Pin1 regulates CtIP polyubiquitination and turnover ( 18 ). WebDec 31, 2024 · Phenotypic observations and statistics of HJ2 and different pin1 mutants. (a) Phenotypes of 7-day-old seedlings of HJ2, pin1c pin1d double mutant (pin1cd), pin1a pin1c pin1d triple mutant (pin1acd ...
Pin1 mutant
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WebJan 20, 2015 · When PIN1 is expressed under the control of the PIN2 promoter in the agravitropic pin2 mutant, it is, in contrast to PIN2, localized predominantly basally (toward root tip) in epidermis cells. Therefore, the auxin transport capacity in basipetal (shootward) direction, necessary for correct gravitropism, is not achieved. WebPIN1 is overexpressed in human cancers, suggesting it promotes tumorigenesis, but depending on the cellular context, it also acts as a tumor suppressor. Here, we review …
WebOur results suggest that PIN1 plays a role in cancer cell proliferation, migration and invasion in a different manner according to the TP53 gene mutation status in HCC. In particular, interaction of PIN1 with mutant TP53 can act as a tumor promoter and increase its oncogenic activities in HCC. MeSH terms Adult WebAug 26, 2024 · The first PIN to be cloned was PIN1 from Arabidopsis thaliana. The pin1 mutant exhibited defective inflorescence development, lacked cauline leaves and floral organs, and had a pin-head trait . Subsequently, seven more …
WebPin1 enhances tumorigenesis in a Li-Fraumeni mouse model and cooperates with mutant p53 in Ras-dependent transformation. In breast cancer cells, Pin1 promotes mutant p53 dependent inhibition of the antimetastatic factor p63 and induction of a mutant p53 transcriptional program to increase aggressiveness. WebPin1 is phosphorylated at S138 by mixed-lineage kinase 3 (MLK3) (Figure 1B) . The phosphorylation of S138 increases isomerase activity . The phosphorylation mimicking mutant S138E showed a fourfold increase in catalytic activity relative to that of the wild-type Pin1, whereas the S138A mutant diminished this activity by about two-fold .
WebParkinson disease. Researchers have identified more than 70 mutations in the PINK1 gene that can cause Parkinson disease, a condition characterized by progressive problems …
The gene encoding Pin1 was identified in 1996 as a result of a genetic/biochemical screen for proteins involved in mitotic regulation. It was found to be essential for cell division in some organisms. By 1999, however, it was apparent that Pin1 knockout mice had a surprisingly mild phenotype, indicating that the enzyme was not required for cell division per se. Further studies later found that loss of Pin1 in mice displays are not only neuronal degenerative phenotypes but … seq ack 番号Webp53 protein is a well-known tumor suppressor factor that regulates cellular homeostasis. As it has several and key functions exerted, p53 is known as “the guardian of the genome” and either loss of function or gain of function mutations in the TP53 coding protein sequence are involved in cancer onset and progression. The Hippo pathway is a key regulator of … the takatso consortiumWebOct 13, 2024 · Abstract. The oncogenic transcription condition B-Myb is an essential regulator of slow cellphone cycle dna whose activation by phosphorylation is still poorly unders seqf myhWebWe tested the polar transport activity of indole-3-acetic acid and the endogenous amount of free indole-3-acetic acid in the tissue of inflorescence axes of the pin1 mutants and wild … the take 2007 123moviesWebFurthermore, we identified a transcriptional signature associated with poor prognosis in breast cancer and, in a cohort of patients, Pin1 overexpression influenced the prognostic … seq harrington hoistWebLoss of function severely affects organ initiation, pin1 mutants are characterised by an inflorescence meristem that does not initiate any flowers, resulting in the formation of a naked inflorescence stem. PIN1 is involved in the determination of leaf shape by actively promoting development of leaf margin serrations. the takaWebNational Center for Biotechnology Information seq heavy vehicle repairs \u0026 maintenance