Knipholone
WebOct 9, 2024 · The African natural product knipholone anthrone and its analogue anthralin (dithranol) enhance HIV-1 latency reversal A sterilizing or functional cure for HIV is currently precluded by resting CD4+ T cells that … WebJan 1, 2024 · Kniphofia foliosa is a flamboyant robust perennial herb which has dense clumps and tick upright rhizomes with leaves at the base. In Ethiopia, it has several vernacular names including Abelbila, Ashenda, Amelmela, Yeznjero Ageda, Shemetmetie and Yezinjero Ageda.
Knipholone
Did you know?
WebJun 26, 2024 · Bulbine-Knipholone interfere with JAK2 protein residues Asn1111 and might down regulate their activity which results to loosing JAK2 potential to activate the PI3K kinase. Indole-3-carbinol, 3,3′-diindolylmethane and their derivatives are able to inhibit PI3K signaling pathway as well as the downstream NF-κB, ... WebSep 10, 2024 · Biological activity and stability analyses of knipholone anthrone, a phenyl anthraquinone derivative isolated from Kniphofia foliosa Hochst. - ScienceDirect Journal of Pharmaceutical and Biomedical Analysis Volume 174, 10 September 2024, Pages 277-285
WebMay 1, 2013 · A new phenylanthrone, named knipholone cyclooxanthrone and a dimeric anthraquinone, 10-methoxy-10,7′- (chrysophanol anthrone)-chrysophanol were isolated from the roots of Kniphofia foliosa... WebJul 25, 2008 · Particular emphasis is given to the stereostructure of knipholone, the most abundant of these naturally occurring phenylanthraquinones. The most recent highlight is the discovery of the first dimeric representatives, named joziknipholones, involving interesting phenomena of--partially or fully restricted--rotation at the sp2-sp2 and sp2-sp3 …
WebKnipholone was also the most effective in increasing the expression of CYP3A4 (8.47 ± 2.5 fold) and CYP2C9 (2.64 ± 0.3 fold) at 10 µM. Docking studies further confirmed the unique structural features associated with knipholones for their superior inductive potentials in the activation of PXR compared to other anthraquinones. WebOur findings demonstrated that both water and methanolic extracts of B. natalensisas well as knipholone, bulbine-knipholone, and 6'-O-methylknipholone dose-dependently increased mRNA expression encoded by CYP2B6, CYP1A2,and ABCB1genes.
WebSep 22, 2024 · Knipholone and knipholone anthrone have been reported not to cause DNA damage on their own but knipholone anthrone caused DNA damage in the presence of copper ions through the generation of hydrogen peroxide (Habtemariam and Dagne, 2009). 4-Nerolidylcatechol has been shown to exhibit low genotoxicity compared to negative …
WebNov 1, 1993 · It was earlier suggested that knipholone (l) may arise as a result of oxidative coupling of chrysophanol with acetylphloroglucinol or its monomethyl ether [1]. How- ever, the occurrence of knipholone anthrone in K. foliosa indicates that the coupling may take place prior to anthraquinone formation. EXPERIMENTAL Plant material. the high deep blue skyWebHere, we screened 216 compounds from the pan-African Natural Product Library and identified knipholone anthrone (KA) and its basic building block anthralin (dithranol) as … the beatles day tripper 1965Webother hand, Knipholone anthrone demonstrated weak to high activity with 26, 48, and 70% cell growth inhibition, respectively. The comparative cytotoxicity of knipholone and knipholone anthrone isolated from K. foliosa in leukaemic and melanocyte cancer cell lines was investigated by Habtemariam [29]. The study revealed the beatles decca auditionWebKnipholone, a selective inhibitor of leukotriene metabolism. Inhibition of leukotriene formation is one of the approaches to the treatment of asthma and other inflammatory … the beatles dead membersWebKnipholone C24H18O8 CID 442753 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity … the higher society new versionWebJan 1, 2007 · Knipholone anthrone [ 4, see Fig. 1] was originally isolated and characterized from an Ethiopian medicinal plant, K. foliosa, Hochst (Asphodelaceae) ( Dagne & Steglich, 1984) and its structural identity with respect to its absolute configuration latter established by quantum chemical CD calculations ( Bringmann et al., 1999a ). the higher clinic tulsaWebFeb 8, 2024 · Abstract. Knipholone is an antiplasmodial phytocompound obtained from the roots of Kniphofia foliosa.Despite several available studies, the molecular drug targets of knipholone in P. falciparum remained unknown. Nowadays, in silico techniques are widely used to study the molecular interactions between compounds and proteins as they … the higher i got