Under an oxidative condition, protein deglycase DJ-1 inhibits the aggregation of α-synuclein via its chaperone activity, thus functioning as a redox-sensitive chaperone and as a sensor for oxidative stress. Accordingly, DJ-1 apparently protects neurons against oxidative stress and cell death. In parallel, … See more Protein deglycase DJ-1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene. See more Gene The gene PARK7, also known as DJ-1, encodes a protein of the peptidase C56 family. The human gene PARK7 has 8 Exons and locates at chromosome band 1p36.23. Protein See more • Parkinson's disease See more • Cookson MR (Jan 2003). "Pathways to Parkinsonism". Neuron. 37 (1): 7–10. doi:10.1016/S0896-6273(02)01166-2. PMID 12526767. S2CID 14513509. • Bonifati V, Oostra BA, Heutink … See more Defects in this gene are the cause of autosomal recessive early-onset Parkinson's disease 7. See more PARK7 has been shown to interact with: • CASK, • EFCAB6, and • PIAS2. See more • Overview of all the structural information available in the PDB for UniProt: Q99497 (Protein/nucleic acid deglycase DJ-1) at the See more WebGet Dow Jones Fut (Jun'23) (@DJ.1:Chicago Board of Trade) real-time stock quotes, news, price and financial information from CNBC.
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WebPARK7/DJ-1 Protein Overview. DJ1, or PARK7, has pleiotropic function that includes roles as a chaperone with protease activity, a transcriptional regulator, and an antioxidant scavenger and redox sensor. DJ1 is also involved in tumorigenesis and in maintaining mitochondrial homeostasis (summary by Ottolini et al., 2013). WebSep 30, 2024 · DJ-1 is a chaperone protein involved in the protection against PD and genetic mutations in this protein have been shown to cause familial PD. However, ... debra hensley obituary
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