WebPercentages of membranous tumor cell staining at each intensity (0 to 3+) were estimated by board-certified pathologists. A sample is considered to exhibit FGFR2b overexpression and is deemed positive when any moderate (2+) or strong (3+) membrane staining in tumor cells is detected. WebMethods. We initiated an umbrella trial (CTONG1702), in the 8 th arm to access the efficacy and safety of AZD3759, an EGFR-TKI with high capability to penetrate the blood-brain barrier, in untreated EGFR-mutant NSCLC with brain or leptomeningeal metastases. Patients received AZD3759 200 mg or 300 mg BID. The primary objective was objective …
Clinical Lung Cancer Vol 23, Issue 7, Pages 547-642
WebThis study constituted of an open-label, phase II adaptive umbrella trial (CTONG 1702) and a real-world study (RWS) (CTONG 1705), which were simultaneously initiated. Untreated … WebBiomarker-Driven Studies With Multi-targets and Multi-drugs by Next-Generation Sequencing for Patients With Non–Small-Cell Lung Cancer: An Open-Label, Multi-center, Phase II Adaptive Umbrella Trial and a Real-World Observational Study (CTONG1702&CTONG1705) Contributors : Si-Yang Maggie Liu; Hong-Hong Yan; Xue … great ormond street staff intranet
384P Prevalence of fibroblast growth factor receptor 2b (FGFR2b ...
Webselect article 385P Efficacy and safety of pyrotinib in untreated, advanced non-small cell lung cancer with HER2 mutations: A parallel, multi-center, multi-cohort patient-centric study (CTONG1702 and 1705) WebMethods:Weinitiatedanumbrellatrial(CTONG1702),inthe8th armto access the efficacy and safety of AZD3759, an EGFR-TKI with high capability to penetrate the blood-brain barrier, in untreated EGFR-mutant NSCLC with brain or leptomeningeal metastases. Patients received AZD3759 200 mg or 300 mg BID. The primary objective was objective response rate ... WebDec 7, 2024 · Researchers planned a phase II clinical trial with an open-label, multi-center design (CTONG1702). Patients with non-small-cell lung cancer (NSCLC) at stages IIIB to … flooring wholesale distributors near me