Coding region instability determinant
WebOct 5, 2001 · Alternatively, the c-fos mRNA contains a coding region element whose ability to destabilize reporter RNAs is inactivated by the insertion of upstream stem-loop structures, indicating that the cis-acting determinants must be translated or at least associated with ribosomes to confer instability (27, 34).
Coding region instability determinant
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WebTerm Information. An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD). Source: GOC:mah , PMID:19029303. annotations to CRD-mediated mRNA stabilization (. to all direct and indirect annotations download (limited to … WebApr 1, 2024 · IGF2BP1 enhances c-MYC expression by protecting the coding region instability sequence (CRD) of its mRNA from endonucleolytic cleavage. ... IGF2BP1 [orthologues include the coding region determinant-binding protein 1 (CRD-BP1) zipcode-binding protein 1 (ZBP1 and IMP1] is a highly conserved RNA binding protein expressed …
WebA 249-nucleotide coding region instability determinant (CRD) destabilizes c-myc mRNA. Previous experiments identified a CRD-binding protein (CRD-BP) that appears to protect the CRD from endonuclease cleavage. However, it was unclear why a CRD-BP is required to protect a well-translated mRNA whose coding region is covered with ribosomes. WebJun 15, 1983 · Here we show that instability determinants are present within various exons of the PAI-2 coding region, most notably within exon 4. Deletion of exon 4 from the full-length PAI-2 cDNA results in a doubling in the half-life of PAI-2 mRNA, whereas a 28-nucleotide region within exon 4 contains binding sites for cytoplasmic proteins.
WebNov 1, 2001 · 3 deletions of the MnSOD coding region determinant of instability. A, Northern analysis of cells co-transfected with pBBB4 and the MnSOD 8/463 fragment inserted into the coding region of-globin ... WebNumerous DNA- and RNA-level functions are embedded in protein-coding regions, which constrains their structure, function, and evolution. Accumulating evidence suggests that such additional, overlapping functions occur preferentially in the coding sequences of intrinsically disordered proteins/regions (IDPs/IDRs), especially in those that are newly incorporated …
WebApr 27, 2001 · The presence of a homologous motif within the coding region of six transcripts, each of which possess coding region instability determinants, suggests that a common coding region element plays a role in the regulation of mRNA decay. DISCUSSION. PAI-2 is an impressively regulated serine protease inhibitor.
WebDec 10, 2024 · The coding region determinant-binding protein (crd-bp) was identified in our lab as a protein that binds, with high specificity, to the coding region of the mRNA encoding c-Myc, a nuclear phosphoprotein and oncogene product. ... (3’-UTR); and a ~250 nucleotide coding region instability determinant (CRD). 4 The CRD encodes part of … should i go to an edward jones dinnerWebMost importantly, the MnSOD coding region determinant functions when placed in the 3′-untranslated region of the β-globin transcript, demonstrating its activity in the absence of ribosome transit. We feel that these data provide a mechanistic basis for both the basal and stimulus-dependent post-transcriptional regulation of MnSOD. satin sleeveless high slit party dressWebFeb 23, 2024 · The authors also constructed a luciferase reporter with an m 6 A-containing region of MYC mRNA critical for IGF2BP binding called the coding region instability determinant (CRD). should i go tanning before vacationWebNeed abbreviation of Coding Region Instability Determinant? Short form to Abbreviate Coding Region Instability Determinant. 1 popular form of Abbreviation for Coding Region Instability Determinant updated in 2024 satin smooth citrus mojito thin film hard waxWebA Coding Region Determinant of Instability Regulates Levels of Manganese Superoxide Dismutase mRNA* Received for publication, May 14, 2001, and in revised form, August 3, 2001 Published, JBC Papers in Press, August 6, 2001, DOI 10.1074/jbc.M104378200 Christopher A. Davis‡, Joan M. Monnier§, and Harry S. Nick§¶ should i go to a chiropractorWebMar 16, 2024 · A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, IGF2BP1 and at least four additional proteins: HNRNPU, SYNCRIP, YBX1, and DHX9. Def: A protein complex that binds to, and promotes stabilization of, mRNA molecules … satin slip dress with beltWebOct 1, 2024 · R27.9 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2024 edition of ICD-10-CM R27.9 became effective on October 1, 2024. This is the American ICD-10-CM version of R27.9 - other international versions of ICD-10 R27.9 may differ. This chapter includes symptoms, … satin slip on dress