WebDec 19, 2024 · To develop a new class of therapy for MMA, we generated a pseudoU-modified codon-optimized mRNA encoding human methylmalonyl-CoA mutase (hMUT), the enzyme most frequently mutated in MMA, and encapsulated it into biodegradable lipid nanoparticles (LNPs). Intravenous (i.v.) administration of hMUT mRNA in two different … WebDec 19, 2024 · To characterize the kinetics of hMUT mRNA, the LNP (Benenato et al., 2024), and the encoded hMUT protein in the liver, we performed a pharmacokinetics (PK) study in wild-type CD1 mice (n = 3 mice).After a single i.v. bolus of 0.5 mg/kg hMUT mRNA injected via the tail vein route, the ionizable lipid was fully metabolized in the liver after 6 …
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WebAug 16, 2024 · mRNA-3705 is designed to instruct the body to restore the missing or dysfunctional proteins that cause MMA and consists of mRNA encoding human MUT, the mitochondrial enzyme commonly deficient in MMA, encapsulated within Moderna’s proprietary lipid nanoparticle (LNP). mRNA-3705 uses the same proprietary LNP … WebMar 16, 2024 · 36. 166. NYPD Chief of Patrol. @NYPDChiefPatrol. ·. Apr 4. This summer, the streets will definitely be hot. Hundreds of your new extensively trained Community Response Team officers will be hitting the streets and taking back your neighborhoods from illegal cars, ATVs, and dirt bikes. Suns out, cops out. #gsd. in the heights あらすじ