Chembl249097
WebMar 31, 2024 · We designed hybrid structures of dasatinib and the previously known EPHA2 binders CHEMBL249097, PD-173955, and a known EPHB4 inhibitor in order to exploit both the ATP pocket entrance as well as the ribose pocket as binding epitopes in the kinase EPHA2. Medicinal chemistry and inhibitor design were guided by a chemical proteomics … WebThe COSMIC website notes an up-regulated expression score for ZC2 in diverse human cancers of 501, which is 1.1-fold of the average score of 462 for the human protein kinases. The down-regulated expression score of 1 for this protein kinase in human cancers was 98% lower than average score of 60 for the human protein kinases.
Chembl249097
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WebSynonyms: 2,4-dianilino pyrimidine, 2, CHEMBL249097, KB-74932, Benzamide,3-[[4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl]amino]- Molecular Formula: C 18 H 17 N 5 O 2: Molecular Weight: 335.359880 [g/mol] H-Bond Donor: 4: H-Bond Acceptor: 6: InChIKey: SFCBIFOAGRZJNX-UHFFFAOYSA-N Web1.Identification Product name: Lck inhibitor 2 Catalog#: 2893DC IUPAC name: 3-[[4-(5-hydroxy-2-methylanilino)pyrimidin-2-yl]amino]benzamide Product use restrictions:Only for research and development use by, or directly under the supervision of,
WebJun 21, 2024 · We designed hybrid structures of dasatinib and the previously known EPHA2 binders CHEMBL249097, PD-173955, and a known EPHB4 inhibitor in order to exploit … Web239 replacement oil filters for GENERAL-MOTORS 96879797. See cross reference chart for GENERAL-MOTORS 96879797 and more than 200.000 other oil filters.
WebWe designed hybrid structures of Dasatinib and the previously known EPHA2 binders CHEMBL249097, PD-173955 and a known EPHB4 inhibitor in order to exploit both the … WebCrystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 1k
Web(2024) Heinzlmeir et al. ChemMedChem. The receptor tyrosine kinase EPHA2 has gained attention as a therapeutic drug target for cancer and infectious diseases. However, EPHA2 research and EPHA2-based therapies have been hampered by the lack of selective small-molecule inhibitors. Herein we report ...
WebAug 6, 2014 · We designed hybrid structures of Dasatinib and the previously known EPHA2 binders CHEMBL249097, PD-173955 and a known EPHB4 inhibitor in order to exploit both the ATP pocket entrance as well as ... rickis pointsWebCrystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 1g rickis north oshawaWebCrystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2i rickis returnsWebTECHNISCHE UNIVERSITÄT MÜNCHEN Lehrstuhl für Proteomik und Bioanalytik When chemical proteomics meets medicinal chemistry: Guided drug discovery towards EPHA2 inhibitors Stepha rickis shacketWebDec 31, 2024 · hybrid structures of Dasatinib and the previously known EPHA2 binders CHEMBL249097, PD-173955 and a known EPHB4 inhibitor in order to exploit both the ATP pocket entrance as well as the ribose pocket as binding epitopes in the kinase EPHA2. Medicinal chemistry and inhibitor design was guided by a rickis save codeWebChEMBL is a manually curated database of bioactive molecules with drug-like properties. It brings together chemical, bioactivity and genomic data to aid the translation of genomic … We would like to show you a description here but the site won’t allow us. Visualise ChEMBL A visual overview of ChEMBL and a starting point for … How to get in touch, find people and get directions to our offices. An important part of EMBL-EBI’s mission is to disseminate cutting-edge … The table below displays ChEMBL targets which are predicted to interact with … rickis newmarketWebDec 31, 2024 · hybrid structures of Dasatinib and the previously known EPHA2 binders CHEMBL249097, PD-173955 and a known EPHB4 inhibitor in order to exploit both the … rickis store hours