Botcinic acid
WebThe first asymmetric total syntheses of botcinins C (18), D (19), E (20), and F (21), botcinic acid (22), botcinic acid methyl ester (23), botcineric acid (26), and 3-O-acetylbotcinic … WebMar 8, 2024 · Botcinic acid is a phytotoxic polyketide involved in the virulence of the gray mold fungus Botrytis cinerea. Here, we aimed to investigate the specific regulation of the cluster of Bcboa genes that is …
Botcinic acid
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WebOct 10, 2006 · The total synthesis of pseudo 2-epibotcinolide (1b) through several featured synthetic approaches has been attained. First, the chiral linear precursors of the nine-membered ring compound is stereoselectively constructed by the asymmetric aldol reaction for producing β-hydroxy ester units. WebJan 2, 2013 · Isotopic labelling experiments and the study of mutants with disrupted genes encoding botcinic acid have revealed a common link in the biosynthesis of the polyketide toxins excreted by Botrytis cinerea: botcinins and botrylactones. Furthermore, the results reported here shed light on the origin of the starter unit, thereby solving a long ...
WebSep 10, 2007 · Scheme 1 outlines the details of the synthesis of 2.Aldol reaction of the titanium enolate derived from the chiral ketone 3, prepared from (S)-lactic acid ethyl ester by a known procedure, 5 with methacrolein 4 gave the desired syn-isomer 5 as the major product in a 7:1 ratio. 6 The diastereomers were separated by column chromatography … WebBotrytis cinerea produces two phytotoxins, the sesquiterpenoid botrydial (BOT) and the polyketide botcinic acid (BOA), which have been shown to be required together for full virulence ( Dalmais et al., 2011 ). We tested …
Webacid of botcinin E (7), and botcinolide has been renamed botcinic acid. Homobotcinolide (6), a botcinolide ana-logue, has also been structurally revised to 8 and renamed … WebHeptelidic acid C15H20O5 CID 10945834 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ...
WebDec 15, 2005 · The biosynthetic origin of the botcinolide skeleton was investigated by means of feeding 13 C- and 2 H-labeled precursors to Botrytis cinerea. Three new compounds, two homobotcinolide derivatives, 3- O -acetylhomobotcinolide ( 5) and 8-methylhomobotcinolide ( 6 ), and a new 11-membered lactone ( 7 ), were isolated.
WebOne of these SMs is botcinic acid, a phytotoxic polyketide produced by the coordinated action of a gene cluster in a subtelomeric region of chromosome (Chr) 1 . The transcription factor (TF) BcBoa13 ( Supplementary Material 2 ) contributes to the transcriptional regulation of this cluster [ 63 ]. tri fold privacy fenceWebJan 1, 2024 · In B. cinerea, the botcinic acid BGC is positioned at the beginning of Chr1 and comprises 13 genes, along with the BcBOA6 and BcBOA9 genes, which encode the two important PKS enzymes (Dalmais et al., 2011, Van Kan et al., 2024). There were several variations in the botcinic acid gene clusters found in the same isolate when compared … tri fold privacy screenWebJan 17, 2011 · Botcinic acid and botcinin lactone derivatives are eight-carbon polyketides consisting of a highly substituted tetrahydropyran ring linked by an ester bound at … terrin whiteWebMar 23, 2006 · The structure of botcinolide was revised on the basis of spectroscopic data and chemical conversion. Botcinolide was originally reported as a nine-membered … terrin williamsWebJan 17, 2011 · The grey mould fungus Botrytis cinerea produces two major phytotoxins, the sesquiterpene botrydial, for which the biosynthesis gene cluster has been characterized previously, and the polyketide botcinic acid. We have identified two polyketide synthase (PKS) encoding genes, BcPKS6 and BcPKS9, that are up-regulated during tomato leaf … trifold privacy screenWebNov 1, 2016 · By a combination of transcriptomic, mutagenesis and metabolomic approaches the genes responsible for the production of botcinic acid and botrydial were identified and significant progress was made in the elucidation of the corresponding polyketidic and terpenic biosynthesis pathways. Expand. 25. View 8 excerpts, references … terrin williams cisaWebAug 1, 2011 · We found only one cluster homologous to a known toxin biosynthesis cluster: the botcinic acid cluster from B. cinerea. Botcinic acid is a polyketide that induces necrosis and chlorosis in... trifold printing