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WebApr 10, 2024 · Acetaminophen is an analgesic (painkiller) and fever-reducer that changes the way the body senses pain and cools the body. It can be used to relieve discomfort from problems like headaches, muscle aches, cramps, sore throat and toothaches. Diphenhydramine, is an antihistamine that has sedative effects. In addition to relieving ... WebApr 6, 2024 · Aspirin and acetaminophen may work better for fevers and headaches. Ibuprofen and naproxen may be better for body aches. For fevers above 102 degrees, it may help to alternate between acetaminophen and ibuprofen every three hours. That's especially true if the fever comes back as the medication wears off. 5. WebJun 15, 2024 · The best OTC pain reliever for: Fever. Acetaminophen (Tylenol) is the optimal pain reliever for regulating the body temperature and relieving any aches and pains that come with a fever, says Kavita Gupta, DO, medical director of the Advocare Pain Institute of South Jersey. It is also considered the safest medication for children. hold times for usaa